Award details

The role of the imprinted gene Zac in pancreatic development and function

Reference	BBS/E/B/0000S187
Principal Investigator / Supervisor	Dr Gavin Kelsey
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	49,601
Status	Completed
Type	Institute Project
Start date	01/05/2007
End date	31/10/2009
Duration	30 months

Abstract

Diabetes mellitus affects nearly 30 million individuals in Europe, decreasing their life quality and expectancy. People with diabetes are no longer able to control the level of sugar in their blood properly, because the hormone, insulin, which normally does this is produced in inadequate amounts. Diabetes comes in two main forms, type 1 and type 2, but in both cases there is a reduction in the number of the cells, the beta cells in the pancreas, that produce the insulin hormone. The reasons for this are not fully known and, although the original causes may differ in type 1 and type 2 diabetes, similar events may have occurred within the beta cells. This knowledge is essential for the development of novel therapies to preserve adequate beta cell mass and thus prevent or cure diabetes. In this project, we shall be studying the function of one particular gene which has been found to control beta cell number and to cause a form of diabetes when its activity is altered.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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