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E coli and mammalian genetic screens for factors that modify DNA methylation

Reference	BBS/E/B/0000Q192
Principal Investigator / Supervisor	Professor Wolf Reik
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	43,994
Status	Completed
Type	Institute Project
Start date	08/08/2006
End date	07/10/2009
Duration	38 months

Abstract

Work with stem cells promises new and exciting applications in regenerative medicine. Somatic cells (any cell in the body other than an egg or sperm) might be taken directly from patients, and their nuclei reprogrammed to a stem cell (that can give rise to most tissues) state by somatic cell nuclear transfer (SCNT) into oocytes. This scenario is difficult, however, because of inefficient epigenetic reprogramming during SCNT, and because of ethical difficulties with obtaining oocytes for this purpose. It is therefore important to begin to identify reprogramming factors that is molecules or enzymes that are able to revert epigenetic modifications in somatic cells to those in stem cells. Epigenetic modifications occur in the form of chemical and other modifications to DNA, which are associated with gene expression and genome function.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	Microbiology, Stem Cells
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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