Award details

Dorthy Hodgkin/GSK Studentship Project:15q11-q13, imprinted genes and mental illness

Reference	BBS/E/B/0000Q156
Principal Investigator / Supervisor	Dr Lawrence Wilkinson
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	41,873
Status	Completed
Type	Institute Project
Start date	01/04/2005
End date	31/03/2008
Duration	36 months

Abstract

This studentship, sponsored by a Dorothy Hodgkin Postgraduate Award in collaboration with GSK plc, will investigate the genetic and epigenetic mechanisms underlying the presence of affective and psychotic symptoms in individuals suffering from Prader-Willi syndrome (PWS), a condition arising from abnormal expression of imprinted genes located in a small region of human chromosome 15 (15q11-q13). This will be done by analyzing blood samples from patients and by exploiting relevant genetic mouse models of the condition. In addition to shedding light on the genetic causes of mental problems in PWS we hope that our experiments will be of more general importance in unearthing novel genes that may be of significance to several common psychiatric disorders, including autism, bipolar disorder and schizophrenia. At the moment, therapies for these conditions are sub-optimal, and new therapeutic avenues are urgently required.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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