Award details

An E. coli genetic screen for factors that modify DNA methylation

Reference	BBS/E/B/0000Q153
Principal Investigator / Supervisor	Professor Wolf Reik
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	11,605
Status	Completed
Type	Institute Project
Start date	08/08/2005
End date	07/08/2007
Duration	24 months

Abstract

Work with stem cells promises new and exciting applications in regenerative medicine. Somatic cells might be taken directly from patients, and their nuclei reprogrammed to a stem cell (pluripotent) state by somatic cell nuclear transfer (SCNT) into oocytes. This scenario is difficult, however, because of inefficient epigenetic reprogramming during SCNT, and because of ethical difficulties with obtaining oocytes for this purpose. It is therefore important to begin to identify `reprogramming factors¿ that is molecules or enzymes that are able to revert epigenetic modifications in somatic cells to those in stem cells.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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