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Functional Analysis of D3 Dopamine Receptor Mutant Mice
Reference
BBS/E/B/0000Q006
Principal Investigator / Supervisor
Dr Nicholas Allen
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
3,437
Status
Completed
Type
Institute Project
Start date
01/10/2000
End date
28/02/2005
Duration
53 months
Abstract
The neurotransmitter dopamine controls a multitude of brain cognitive and motor functions. The effects of dopamine release are mediated by neurons that express dopamine receptors, which fall into two classes, the D1-like receptors that act to increase intracellular cAMP and the D2-like receptors that act to reduce cAMP levels. The D3 receptor is a D2-like receptor with a restricted pattern of expression in the brain predominately within the mesolimbic system, and has been implicated in the aetiology of disorders such as schizophrenia. Neurons express the D3 receptor as part of an integrated dopamine system. The aim of this project is to analyse the mechanisms that determine the specification and proper neuroanatomical development of D3R expressing neurons during gestation.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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