BBSRC Portfolio Analyser
Award details
Dorothy Hodgkin/GlaxoSmithKline Studentship: MicroRNA and regulation of autoimmunity
Reference
BBS/E/B/0000N191
Principal Investigator / Supervisor
Professor Francesco Colucci
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
90,949
Status
Completed
Type
Institute Project
Start date
10/01/2007
End date
31/12/2009
Duration
36 months
Abstract
Regulation of gene expression is important in health and disease. For example our white blood cells fight infection by turning on a set of genes that produce inflammatory factors necessary to rid the infection. But a mismanagement of such resources in time or space can cause diseases such as septic shock and chronic inflammation, i.e. arthritis. Small RNA molecules dubbed micro-RNAs are emerging as powerful regulators of gene expression in many biological processes, including immunity, but also cancer, growth and development. Our project in collaboration with GlaxoSmithKline aims at defining the microRNAs that regulate the development and function of a special set of lymphocytes, the natural killer cells, which are key players in transplantation, reproduction, infection and cancer.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
Immunology, Stem Cells
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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