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Dorthy Hodgkin/GSK Studentship Project:15q11-q13, imprinted genes and mental illness
Reference
BBS/E/B/0000N148
Principal Investigator / Supervisor
Dr Lawrence Wilkinson
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
30,629
Status
Completed
Type
Institute Project
Start date
01/04/2005
End date
31/03/2008
Duration
36 months
Abstract
This studentship, sponsored by a Dorothy Hodgkin Postgraduate Award in collaboration with GSK plc, will investigate the genetic and epigenetic mechanisms underlying the presence of affective and psychotic symptoms in individuals suffering from Prader-Willi syndrome (PWS), a condition arising from abnormal expression of imprinted genes located in a small region of human chromosome 15 (15q11-q13). This will be done by analyzing blood samples from patients and by exploiting relevant genetic mouse models of the condition. In addition to shedding light on the genetic causes of mental problems in PWS we hope that our experiments will be of more general importance in unearthing novel genes that may be of significance to several common psychiatric disorders, including autism, bipolar disorder and schizophrenia. At the moment, therapies for these conditions are sub-optimal, and new therapeutic avenues are urgently required.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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