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Mouse to Arabidopsis: transkingdom approaches to discovery of imprinted genes and analysis of genomic context
Reference
BBS/E/B/0000N112
Principal Investigator / Supervisor
Dr Gavin Kelsey
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
8,220
Status
Completed
Type
Institute Project
Start date
01/04/2004
End date
31/03/2007
Duration
36 months
Abstract
Some genes are distinct because only one copy of the two transmitted by parents is active. These genes are said to be imprinted. Imprinted genes are important in reproduction in mammals, and imprinting breakdown is linked to disease. Imprinting is also important in flowering plants, where it affects agronomically important traits such as seed size. The selective pressures that have led to the evolution in mammals and plants may be similar, and it is possible that the control mechanisms on the DNA sequence may also be similar. There are many imprinted genes known in the mouse but few in plants. In this project, we aim to apply molecular methods that have been successful in mammals to the identification of imprinted genes in a model plant, Arabidopsis. With the discovery of imprinted genes in this plant, we shall begin to compare DNA sequence and other features of imprinting across the animal and plant kingdoms.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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