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MRC DTA Studentship: Study of molecular events that delay Wallerian degeneration
Reference
BBS/E/B/0000M984
Principal Investigator / Supervisor
Professor Michael Philip Coleman
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
100,996
Status
Completed
Type
Institute Project
Start date
01/10/2005
End date
30/09/2008
Duration
36 months
Abstract
We have shown that the degeneration of axons, the long fibre-like projections in our nerves, brain and spinal cord, follows a similar mechanism in both injury and disease. We have also identified a gene, named WldS, that delays axon degeneration in both circumstances and this project is part of our efforts to understand how this gene works. The protein that this gene encodes is targeted to discrete spot-like regions inside the cell's nucleus and one aim of this project is to understand how this happens and whether the spots are required for the neuroprotective effect. Other aims are to understand the importance of an enzyme activity intrinsic to the WldS protein and to investigate which other proteins are required to mediate its effect.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Ageing, Neuroscience and Behaviour
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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