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MRC DTA Studentship: Role of IGFBP-5 in cell fate, growth and development

Reference	BBS/E/B/0000M974
Principal Investigator / Supervisor	Dr Jennifer Pell
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	93,055
Status	Completed
Type	Institute Project
Start date	01/10/2004
End date	30/09/2007
Duration	36 months

Abstract

The decision of cells to proliferate versus exiting the cell cycle and differentiating for a specialised function is fundamental to development. This is in part regulated by a family of growth factors, called IGFs. IGFs are so potent that their activity is tightly regulated by a family of binding proteins (IGFBPs). It is now clear, however, that specific IGFBPs can have additional roles in the regulation of cell fate. The aim of this project is to determine the function of the most conserved IGFBP, IGFBP-5, in myoblast differentiation, which can be used as an excellent model for cell fate decisions.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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