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MRC Quota Studentship: Chromatin remodelling mechanisms in the immunoglobulin locus
Reference
BBS/E/B/0000M940
Principal Investigator / Supervisor
Dr Anne Corcoran
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
20,717
Status
Completed
Type
Institute Project
Start date
01/10/2002
End date
26/04/2006
Duration
43 months
Abstract
This project aims to understand how B lymphocytes in the immune system regulate DNA on the chromosome that generates antibodies that fight infection. This DNA region contains 200 genes that are used in many different combinations to make the large repertoire of antibodies we need. Once the genes are recombined they are transcribed into RNA, and then translated into protein. There are several DNA sequences in this large DNA region that are essential for expression of these genes, but they occur at a distance from the genes, The aim of the project is to determine whether these DNA sequences physically move to make contact with the genes, or whether they can act at a distance. Understanding how they work will help us to design therapies for diseases in which antibody production is defective.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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