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MRC Quota Studentship: Investigation of cellular functions of the imprinted gene Gnasx1
Reference
BBS/E/B/0000M929
Principal Investigator / Supervisor
Dr Gavin Kelsey
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
20,733
Status
Completed
Type
Institute Project
Start date
10/01/2002
End date
31/05/2006
Duration
53 months
Abstract
We inherit a set of genes from our mother and from our father. For most genes, both copies are equally active irrespective of their parentage. A few genes defy this expectation: only one copy of an `imprinted¿ gene is normally expressed. Consequently, developmental processes in which imprinted genes function are especially susceptible to the effect of mutation. Imprinting is particularly important in aspects of growth control of the fetus and neurological effects in infants. We are investigating the effects on neonatal endocrinology caused by imprinting at a complex imprinted locus called Gnas, which encodes an important intracellular signalling molecule. As well as providing an understanding of how the products of oppositely imprinted genes interact, this work will assist in the understanding of the complex endocrine and neuroendocrine disorders which result from lesions in the equivalent human gene locus.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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