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MRC Industrial CASE studentship: Tristetraprolin in B-lymphocyte development
Reference
BBS/E/B/0000M740
Principal Investigator / Supervisor
Dr Martin Turner
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
154,583
Status
Completed
Type
Institute Project
Start date
01/10/2009
End date
30/09/2013
Duration
48 months
Abstract
The B cell is a crucial component of the normal immune system, however its dysregulation can lead to certain types of leukaemia, lymphoma and myeloma. This project aims to establish the role of a gene called TIS11 in the regulation of cell death and differentiation (specialisation) in the B cell. The main focus will be the generation and analysis of a mouse model in which TIS11 is deleted in B cells. We will also test the effects of overexpression of TIS11 in cultured B cells.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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