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MRC DTG Studentship: The role of a novel sequence element in activation of the murine beta globin locus
Reference
BBS/E/B/0000M737
Principal Investigator / Supervisor
Dr Peter Fraser
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
114,317
Status
Completed
Type
Institute Project
Start date
01/10/2008
End date
30/09/2012
Duration
48 months
Abstract
Hemoglobinopathies are the most common genetics diseases world-wide and represent an enormous clinical burden. To date there are no effective strategies for hemoglobin defects that do not have serious unwanted side effects. A promising strategy is to re-activate the fetal globin genes which, if expressed in adults, can alleviate the symptoms of most hemoglobinopathies, including sickle cell anemia. We have recently obtained a mouse mutant that has a single base defect in the globin locus that renders the entire locus inactive in adult erythroid cells. We are investigating the basic molecular mechanisms controlled by this sequence element in activation and transcription control of globin gene expression during development and differentiation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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