Award details

MRC DTG Studentship: Gene recruitment to transcription factories

Reference	BBS/E/B/0000M723
Principal Investigator / Supervisor	Dr Peter Fraser
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	142,396
Status	Completed
Type	Institute Project
Start date	01/10/2007
End date	30/09/2011
Duration	48 months

Abstract

The mammalian genome consists of over 25,000 genes but only about half of them are expressed (copied from DNA to RNA) in any given cell type. Each cell type uses a unique subset of these genes while the rest are packaged away into condensed structures. Rather than being a simple string of DNA sequences, our work and that of others has shown that genes interact with other genes and DNA sequences in the nucleus of cells in ways that can effect their activity. Not only do individual chromosomal strings of DNA fold in certain ways to affect gene activity, genes on different chromosomes can interact in 3 dimensional space to alter or affect gene activity. In this project we will assess the 3 dimensional reorganization that occurs in cell nuclei in which specific genes have been artificially induced to switch on. These experiments will provide vital new information to help us to understand how the genome is co-ordinately controlled during red blood cell production. This information is important to understand the regulatory mechanisms of the genome and how it is controlled in health and disease.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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