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Genomic imprinting: analysis of phenotypic consequences and the mechanisms leading to imprinted expression
Reference
BBS/E/B/0000M488
Principal Investigator / Supervisor
Dr Gavin Kelsey
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
451,406
Status
Completed
Type
Institute Project
Start date
01/10/2000
End date
30/09/2005
Duration
60 months
Abstract
We inherit a set of genes from our mother and from our father. For most genes, both copies are equally active irrespective of their parentage. A few genes defy this expectation: only one copy of an `imprinted¿ gene is normally expressed. Imprinted genes are particularly important in controlling growth of the fetus, aspects of behaviour of infants, and in cancer risk: developmental processes in which imprinted genes function may be especially susceptible to the effect of mutation. In this project we shall be examining the effects of imprinted genes on development and physiology using genetic models. We shall also be investigating how the gene copies inherited from the mother and father are marked differently during development of the germ cells and how such marks lead to differences in their activity in the offspring.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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