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Award details
Control of immunoglobulin rearrangement and chromatin accessibility by the transcription factor, Pax5
Reference
BBS/E/B/0000M449
Principal Investigator / Supervisor
Dr Anne Corcoran
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
229,016
Status
Completed
Type
Institute Project
Start date
01/10/1999
End date
28/02/2004
Duration
53 months
Abstract
Genes that make antibodies must be unfolded and rejoined accurately in many different ways to make the large number of antibodies that we need to fight infection. This project will test whether this folding process is controlled by the protein, Pax5, which is essential for making antibodies. Inaccurate unfolding can cause leukaemias. Over expression of Pax5 is associated with some leukaemias and we propose that this may be due to excessive unfolding of antibody genes. These studies will help our understanding of how this important process occurs normally, how it can go wrong, and may identify ways to prevent or correct mistakes.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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