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Award details
A knockout analysis of placental and postnatal catchup growth
Reference
BBS/E/B/0000M442
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
130,341
Status
Completed
Type
Institute Project
Start date
01/10/1999
End date
30/09/2002
Duration
36 months
Abstract
The placenta is an important organ for nutrition of the baby in the womb. If the placenta is too small, or otherwise deficient, the baby can be born too small. Very small babies sometimes have a higher risk of diseases later in life, such as diabetes or heart disease. We have created a model system in the mouse, where the placenta is small and its functions possibly impaired. We will investigate whether nutrients do not pass normally through these small placentae, and whether this explains why the pups are born small. This will create an important model system for factors that cause babies to be small, and will enable the more precise definition of disease risk in later life.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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