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Physiological importance of phospholipase D signalling

Reference	BBS/E/B/0000M243
Principal Investigator / Supervisor	Professor Michael Wakelam
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	34,700
Status	Completed
Type	Institute Project
Start date	01/07/2009
End date	30/06/2014
Duration	60 months

Abstract

Hormones, neurotransmitters (chemicals released from nerve cells) and growth factors regulate the body's functions by activating processes in cells that produce signals to control the way a cell grows, divides, moves or secretes. One of these signalling pathways involves activation of the enzyme phospholipase D which produces a messenger called phosphatidic acid. Studies in cells in tissue culture have suggested that this pathway is activated in many responses and is involved in processes such as how inflammation is activated, how cells move and how they secrete factors. There is a need to understand how these pathways are regulated and the precise roles played by this signalling event, since distortion of the regulation is implicated in inflammatory disorders and other diseases including cancer. The only way to understand this physiological role is to generate and study a genetically modified mouse model. We will isolate cells from the mice and thereby characterise the role and regulation of the signalling. This work has the potential to identify targets for future therapeutic intervention.

Summary

unavailable

Committee	Research Committee A (Animal disease, health and welfare)
Research Topics	Immunology, Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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