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An in vitro compartmentalisation screen for demethylases in mammals

Reference	BBS/E/B/0000M236
Principal Investigator / Supervisor	Professor Wolf Reik
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	89,636
Status	Completed
Type	Institute Project
Start date	01/01/2009
End date	31/12/2011
Duration	36 months

Abstract

Work with stem cells promises new and exciting applications in regenerative medicine. Somatic cells (any cell in the body other than an egg or sperm) might be taken directly from patients, and their nuclei reprogrammed to a stem cell state (that can give rise to most tissues) by introduction of some key reprogramming factors, resulting in the generation of induced pluripotent stem (iPS) cells. This process is inefficient and often incomplete, however, because of inefficient epigenetic reprogramming during generation of iPS cells. It is therefore important to begin to identify 'reprogramming factors' that is molecules or enzymes that are able to revert epigenetic modifications in somatic cells to those in stem cells. Epigenetic modifications occur in the form of chemical and other modifications to DNA, which are associated with gene expression and genome function. We have developed a screen which we think will be able to identify some of the factors that are important for epigenetic reprogramming.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	Stem Cells
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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