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Mechanisms of epigenetic gene silencing caused by the long non-coding Kcnq1ot1 RNA - a key regulator of BWS
Reference
BBS/E/B/0000M226
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
68,925
Status
Completed
Type
Institute Project
Start date
01/07/2008
End date
30/06/2011
Duration
36 months
Abstract
Imprinted genes are those genes only expressed (copied into RNA) from one of the parental chromosomes. These genes have important roles in embryonic development, growth, and human diseases including cancer. Imprinted genes occur in clusters in the genome, and some clusters are regulated by long non-coding RNAs (RNA which does not code for proteins), which somehow inactivate the genes located next to them in the cluster. This project will investigate the mechanisms by which the non-coding RNA Kcnq1ot1, deregulation of which underlies the human overgrowth and cancer syndrome Beckwith-Wiedemann syndrome, regulates gene silencing. This will include investigations of physical interactions of the RNA with the gene cluster, and the consequent change of higher order organisation of the gene cluster.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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