BBSRC Portfolio Analyser
Award details
Molecular dissection of the role of ARAP3 in angiogenesis
Reference
BBS/E/B/0000M221
Principal Investigator / Supervisor
Dr Sonja Vermeren
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
43,495
Status
Completed
Type
Institute Project
Start date
01/01/2008
End date
31/03/2012
Duration
51 months
Abstract
Consistent delivery of oxygen and nutrients to all cells is vital for multicellular organisms. This need becomes particularly apparent during embryonic development or during growth of tumours. To be successful, in both cases, blood vessels need to be formed, by a specialised process termed angiogenesis. Angiogenesis is a very comlex process which requires the co-ordinated action of multiple cellular factors within specialised cells. When the process fails, the developing embryo (or tumour) dies. ARAP3 is a signalling protein which regulates cross-talk between small GTPase proteins of different subfamilies, and which is regulated itself by phosphoinositide 3OH-kinase (PI3K), a key regulator of many cellular processes. We have very recently derived two ARAP3 models, where we can analyse the results of loss of ARAP3 or a situation where the protein is no longer under the control of PI3K. We find that both loss of ARAP3 and loss of its regulation by PI3K leads to embryonic death due to an angiogenesis defect, indicating that ARAP3 is required for embryonic angiogenesis and that this is regulated by PI3K. This project aims to understand why this happens, and which of the small GTPases that ARAP3 talks to are important for this.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search