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Analysis of microRNA function in B lymphocytes
Reference
BBS/E/B/0000M214
Principal Investigator / Supervisor
Dr Elena Vigorito
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
26,411
Status
Completed
Type
Institute Project
Start date
01/09/2007
End date
31/08/2012
Duration
60 months
Abstract
B lymphocytes are a type of white blood cells. They provide long term immunity following disease or vaccination, being therefore essential for normal health. Deregulation of B lymphocytes may lead to autoimmune diseases or cancer. Consequently, understanding the molecular mechanisms of B cell differentiation (specialisation) is an important priority. MicroRNAs (miRNAs) are a recently discovered type of molecule increasingly recognised as being essential for many biological processes. Until recently, nothing has been known on the role of specific microRNAs in B lymphocyte differentiation, but it is anticipated that microRNAs will be shown to be important regulators of B cell function. In this regard, I have observed that one microRNA, miR-155, regulates important functions of B cells necessary for antibody secretion. In order to fight infection, B lymphocytes make antibodies to recognise foreign pathogens. This project is designed to gain a better understanding of how miR-155 and other microRNAs work. MicroRNA expression (production) is altered in cancer and it is likely that in the future pharmaceutical companies will target them. The knowledge obtained from my proposed work will provide insights into a new mechanism regulating lymphocyte differentiation which in the long term may impact on the design of therapies for treatment of human diseases.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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