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Award details
The role of PtdIns3P in the killing of bacteria and fungi by the neutrophil NADPH oxidase
Reference
BBS/E/B/0000M211
Principal Investigator / Supervisor
Dr Phillip Hawkins
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
64,815
Status
Completed
Type
Institute Project
Start date
01/07/2007
End date
31/03/2012
Duration
57 months
Abstract
This proposal is aimed at understanding some fundamental principles of how neutrophils (a type of white blood cell) fight bacterial and fungal infections and will therefore aid our general understanding of what might go wrong in some cases of infection and inflammation. Further, through existing academic collaborations with several pharmaceutical companies this work will contribute to the development of better PI3K inhibitors and some of the mouse models developed will provide 'proof of principle' for the concept that specific oxidase components could be potential targets for anti-inflammatory drugs.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Immunology, Microbiology, Pharmaceuticals
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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