Award details

The mechanism and regulation of axonal transport of tau

Reference	BBS/E/B/0000M108
Principal Investigator / Supervisor	Professor Michael Philip Coleman
Co-Investigators / Co-Supervisors	Dr Piers Emson
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	293,482
Status	Completed
Type	Institute Project
Start date	27/09/2004
End date	30/03/2011
Duration	78 months

Abstract

Nerve fibres, both in the central nervous system (brain and spinal cord) and peripheral nervous system (e.g. limbs) are the largest cellular structures in the body. Most or all proteins are made in one part of the cell and must be delivered to the nerve fibres where they carry out tasks such as providing structural support for the nerve fibre, or allowing electrical impulses to pass along the fibre. If this transport process fails, nerves die, and this process is likely to underlie much of the neurodegeneration in disorders such as Alzheimer's disease and motor neuron disease. One particular protein, tau, is known to be structurally altered in related disorders and studying the effects of these alterations should provide important clues as to how nerves die. We are studying how changes to tau protein affect how it is transported along the nerve.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Ageing, Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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