Award details

Functional roles of the novel guanine-nucleotide exchange factors P-Rex1 and P-Rex2

Reference	BBS/E/B/0000M090
Principal Investigator / Supervisor	Dr Heidi Welch
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	501,339
Status	Completed
Type	Institute Project
Start date	01/10/2003
End date	31/01/2008
Duration	52 months

Abstract

We have recently discovered an enzyme call P-Rex1 that seems to be important for some cells of our immune system to function properly. One of the aims of this project is to define exactly how wide ranging the functions of P-Rex1 really are. We are also in the process of characterising another enzyme similar to P-Rex1, called P-Rex2. Another aim of this project is to define the functions of P-Rex2. The study should further our understanding of the functional roles of the P-Rex family and, most importantly, determine signalling specificity between different members of the P-Rex family and between the P-Rex family and other families of guanine-nucleotide exchange factors (GEFs).

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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