Award details

The function of Vav family proteins in immunity and tolerance

Reference	BBS/E/B/0000M050
Principal Investigator / Supervisor	Dr Martin Turner
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	557,474
Status	Completed
Type	Institute Project
Start date	01/07/2002
End date	30/06/2007
Duration	60 months

Abstract

The immune system has evolved to protect our bodies from the constant attack of harmful micro-organisms. To do this successfully the immune system utilises cells and molecules that convey information about the nature of the attacking micro-organisms and employs mechanisms to prevent the immune system from attacking our own cells (tolerance). This information is conveyed into the immune cell by cell by cell-surface receptors that are linked to molecules responsible for signal amplification, interpretation and attenuation (signal transduction). A large number of genes encoding proteins whose function is signal transduction have been discovered, but in many cases little is known regarding their importance or mode of action. One family of genes contributing to these signalling processes in immune cells are the so-called Vav genes of which there are three known members. The experimental approaches described in this fellowship application are designed to establish how the three known Vav genes regulate the function of immune cells. By combining molecular, cellular and whole animal approaches I expect to define the function, mechanism of action and physiological importance of this family of proteins. The results will provide a greater insight into the mechanisms by which the antigen receptor controls immune cell activation and tolerance. This knowledge will contribute to our understanding of the genetics of autoimmunity and may highlight Vav proteins as a point for manipulation during infectious and non-infectious disease.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search