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BBSRC Strategic ResearchStudentship: The role of dicer and RNAi in imprinting and DNA methylation in the mouse
Reference
BBS/E/B/0000L997
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
116,224
Status
Completed
Type
Institute Project
Start date
01/10/2005
End date
30/09/2009
Duration
48 months
Abstract
Epigenetic marking and imprinting plays important roles in mammalian development and disease. Epigenetic modifications such as DNA methylation or histone tail marks can be acquired by different mechanisms and triggers. In yeast and plants it is established that small RNAs (RNAi) can lead to epigenetic marking. In mammals it is not known if the same pathway exists. This student project uses mouse models which lack a key enzyme (Dicer) that is essential for the production of small RNAs potentially involved in epigenetic marking. The effects on DNA methylation and imprinting will be tested.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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