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BBSRC DTA Studentship: Mechanisms of axon protection in neurodegenerative disorders

Reference	BBS/E/B/0000L989
Principal Investigator / Supervisor	Professor Michael Philip Coleman
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	78,133
Status	Completed
Type	Institute Project
Start date	01/10/2005
End date	30/09/2008
Duration	36 months

Abstract

Axon degeneration can be initiated by many diverse stimuli either in experimental settings or in human injury and disease, where it is of fundamental importance to neurodegenerative symptoms. We have shown that the degeneration of axons, the long fibre-like projections in our nerves, brain and spinal cord, follows a similar mechanism in both injury and disease. We have also identified a gene, named WldS, that delays axon degeneration in both circumstances. One aim of this project is to test the hypothesis that in some circumstances the WldS gene might prevent axon degeneration altogether rather than simply delay it. A second aim is to image axon degeneration in real time to better understand its mechanism.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Ageing, Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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