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BBSRC Special Committee Studentship: How genes are marked to become imprinted

Reference	BBS/E/B/0000L976
Principal Investigator / Supervisor	Dr Gavin Kelsey
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	60,371
Status	Completed
Type	Institute Project
Start date	01/10/2004
End date	31/05/2008
Duration	44 months

Abstract

We inherit a set of genes from our mother and from our father. For most genes, both copies are equally active irrespective of their parentage. A few genes defy this expectation: only one copy of an imprinted gene is normally expressed. Consequently, developmental processes in which imprinted genes function are especially susceptible to disturbance by mutations, for example, problems in imprinting give rise to problems in growth of babies in the womb and may predispose to some cancers. The molecular events that mark gene copies from fathers and mothers that result in the unequal activity of imprinted genes are poorly understood, but it is known that such marks must be applied in germ cells - the egg and sperm. In this project, we are investigating how these molecular marks are applied to imprinted genes: what is the nature of the DNA sequences responsible and what are the events that mark them.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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