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BBSRC DTA Studentship : Novel GTPase family in immune cells: roles in apoptosis and quiescence
Reference
BBS/E/B/0000L973
Principal Investigator / Supervisor
Dr Geoff Butcher
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
142,120
Status
Completed
Type
Institute Project
Start date
01/10/2004
End date
30/09/2008
Duration
48 months
Abstract
Both the development of a mature immune system as well as its healthy performance depend upon the action of numerous genes and proteins that act in an orchestrated fashion to achieve the desirable end of protecting the individual from virulent pathogens. The human, mouse and rat genome sequencing projects have opened our eyes to scores of new genes that are actively expressed in the immune system and whose roles we need to understand and to fit into the full picture of how immunity works. We have chosen to investigate the Immune Associated Nucleotide (Ian) genes, that code for a recently described family of signalling proteins. They have been linked to autoimmune diseases such as type I diabetes and to the response of mice in experimental models of malaria. We think that they may be involved in regulating the size and activation state of populations of white blood cells such as lymphocytes and macrophages. We aim to identify the intracellular processes controlled or performed by these proteins.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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