Award details

BBSRC DTA Studentship: The cloning and expression of novel adrenergic adrenergic receptors from the protochordate Amphioxus

Reference	BBS/E/B/0000L970
Principal Investigator / Supervisor	Dr Peter Evans
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	53,101
Status	Completed
Type	Institute Project
Start date	01/10/2004
End date	30/09/2008
Duration	48 months

Abstract

An analysis of the genome of the model organism, Drosophila, has revealed the existence of novel genes that are structurally similar to vertebrate beta-adrenergic receptors. We have shown that the pharmacology of the founding member of this new family of receptors is highly unusual in that it does not display a typical adrenergic receptor pharmacology and can also respond to insect steroids. This project aims to clone and characterize related homologues identified from the protochordate Amphioxus, in terms of their pharmacology and mode of action. It will increase our basic knowledge of how cells in nervous systems "talk" to each other and of the way in which adrenergic receptors have evolved.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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