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BBSRC CASE Studentship: Signalling integration in T cell activation
Reference
BBS/E/B/0000L967
Principal Investigator / Supervisor
Professor Klaus Okkenhaug
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
20,899
Status
Completed
Type
Institute Project
Start date
01/10/2004
End date
30/09/2006
Duration
24 months
Abstract
To elicit an immune response, T cells need to receive stimuli from several receptor proteins on the cell surface. The principal of these is the T cell receptor (TcR), which is responsible for the molecular recognition of invading pathogens. Additional receptor signals are needed, however, in order to fully activate T cells. One of these is provided by a receptor called CD45 and another is provided by CD28. The TcR, CD45 and CD28 all regulate the activity of key enzymes, but through different mechanisms. The aim of the project is to investigate how the TcR, CD45 and CD28 each contribute to full T cell activation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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