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BBSRC DTA Studentship: Posttranscriptional mediators of B cell fate decisions
Reference
BBS/E/B/0000L966
Principal Investigator / Supervisor
Dr Martin Turner
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
49,222
Status
Completed
Type
Institute Project
Start date
01/10/2004
End date
30/09/2007
Duration
36 months
Abstract
B-lymphocytes are responsible for the production of antibodies recognising antigen that is part of an invading micro-organism. Specific antibodies provide protective immunity and form the basis of all successful vaccines. This project is designed to understand in greater detail the molecular mechanisms that regulate antibody production. Specifically we aim to define the function of a class of genes, that we predict will regulate the final stages of B cell differentiation and antibody production. These genes encode proteins which have the capacity to bind messenger RNA (the nucleic acid molecules that contain information required for the translation of DNA sequence into protein sequence) and trigger its destruction. By degrading specific messenger RNA in activated B cells we predict that these genes control B cell differentiation and antibody production.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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