BBSRC Portfolio Analyser
Award details
BBSRC Industrial CASE studentship: Regulation of T helper cell differentiation, cytokine expression and secretion by PI3K
Reference
BBS/E/B/0000L746
Principal Investigator / Supervisor
Professor Klaus Okkenhaug
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
88,056
Status
Completed
Type
Institute Project
Start date
01/10/2009
End date
30/09/2013
Duration
48 months
Abstract
Cells of the immune system communicate by secreting different proteins called cytokines, leading to an orchestrated defence against infectious agents. T cells secrete many of these cytokines and are essential for keeping vertebrate animals free from infectious diseases. The timing of cytokine production, the type of cytokines produced and amount of cytokine produced are tightly controlled processes. Alterations in any of these parameters can lead to increased susceptibility to infection and/or to inflammatory diseases such as rheumatoid arthritis. One of the enzymes within T cells that regulates these proteins is called PI3K. We will determine which genes PI3K regulates to promote cytokine production and by which mechanism PI3K does so.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search