BBSRC Portfolio Analyser
Award details
BBSRC DTG studentship: The function of Tis11 proteins in myogenesis
Reference
BBS/E/B/0000L741
Principal Investigator / Supervisor
Dr Jennifer Pell
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
91,831
Status
Completed
Type
Institute Project
Start date
01/10/2009
End date
30/09/2013
Duration
48 months
Abstract
Myogenesis is the process by which unspecialized cells express specific genes and silence others to ultimately become muscle fibres that contain muscle-specific proteins. When a gene is expressed ('transcribed') a messenger RNA (mRNA) transcript is generated, which usually encodes a protein. However, it is now known that gene transcription is only one aspect of regulation; the rate at which mRNA is degraded is also very important. Obviously, a rapidly degraded RNA will not have the opportunity to encode as much protein as a long-lived RNA. The aim of this project is to examine the function of a family of proteins (termed Tis11) that bind to the ‘ends’ of RNA and induce RNA degradation. Several key myogenic mRNAs (e.g. Myogenin) have candidate Tis11 binding sites and are therefore candidate Tis11 targets. We will also investigate the way in which Tis11 proteins themselves are regulated.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
Stem Cells
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search