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BBSRC DTG: Co-operation between Rac-GEFs in neutrophils
Reference
BBS/E/B/0000L732
Principal Investigator / Supervisor
Dr Heidi Welch
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
198,311
Status
Completed
Type
Institute Project
Start date
01/10/2008
End date
30/09/2012
Duration
48 months
Abstract
Rac is a protein that regulates the function of white blood cells called neutrophils. Rac is activated by a class of enzymes called guanine nucleotide exchange factors (GEFs). Currently, three families of GEFs are known to activate Rac in neutrophils, but it is unknown to which extent they play specific roles, or whether interactions exist between them. The aim of this project is to assess the extent to which GEFs co-operate in neutrophils. Cells deficient in GEFs of one or more families will be compared to cells deficient in Rac.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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