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BBSRC DTG: Signalling pathways of novel phospholipase D enzymes
Reference
BBS/E/B/0000L730
Principal Investigator / Supervisor
Professor Michael Wakelam
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
118,681
Status
Completed
Type
Institute Project
Start date
01/10/2008
End date
30/09/2012
Duration
48 months
Abstract
Tumour cells release large amounts of vesicles (small membrane-enclosed sacs) rich in molecules that promote cell proliferation, migration and survival, and are known to promote the progression of cancer. We have recently identified that autotaxin is also associated with these vesicles. Autotaxin is an enzyme that generates messenger molecules that promote cell proliferation, migration and survival. In this project we will seek to understand the role that autotaxin and the vesicles play in the progression of cancer, and to investigate how the release of autotaxin and vesicles from tumour cells is regulated.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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