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BBSRC DTG: Regulation of lymphocyte apoptosis by novel immune cell GTPases
Reference
BBS/E/B/0000L728
Principal Investigator / Supervisor
Dr Geoff Butcher
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
196,549
Status
Completed
Type
Institute Project
Start date
01/10/2008
End date
30/09/2012
Duration
48 months
Abstract
Homeostasis is the ability of a cell, tissue or organism to regulate its internal environment to maintain a stable, constant condition. The homeostasis of mature lymphocyte (a type of white blood cell) populations is essential for the health of vertebrate animals including humans. Disturbance of this homeostasis by infectious pathogens, by ageing or by some therapeutic treatments can be associated with reduced immune resistance or autoimmune disease. Many genes and proteins, some known, others yet to be identified, contribute to maintaining pools of naïve T and B lymphocytes that have diverse repertoires of antigen receptors (proteins which bind to antigens). Antigens are molecules that are recognised by the immune system.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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