BBSRC Portfolio Analyser
Award details
The role of Pax7 in muscle satellite stem cells
Reference
BBS/E/B/0000L721
Principal Investigator / Supervisor
Dr Jennifer Pell
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
210,873
Status
Completed
Type
Institute Project
Start date
01/10/2007
End date
30/09/2011
Duration
48 months
Abstract
As animals age, they lose muscle mass and existing muscle becomes less strong and has a higher fat content. After birth, muscle fibre number is fixed. Muscle mass and muscle repair are enabled by the activation of muscle precursor cells, called adult satellite stem cells. These special cells contain a unique protein called Pax7. Animals lacking Pax7 are born growth retarded and die soon after birth because muscle satellite cells die. The aim of this project is to determine the role of Pax7 in muscle satellite cell survival, and to find out the mechanisms responsible for Pax7 synthesis and action.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Stem Cells
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search