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BBSRC DTG studentship (Fees only): Epigenetic reprogramming in the germline
Reference
BBS/E/B/0000L719
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
166,318
Status
Completed
Type
Institute Project
Start date
01/10/2007
End date
30/09/2011
Duration
48 months
Abstract
Mammalian germ cells (eggs and sperm) have enormous potential for regenerating a rejuvenated genome, in other words the germline is immortal, while somatic cells (any cell in the body other than an egg or sperm) undergo ageing and eventually die. One process that is likely to play a crucial role in rejuvenation is ‘epigenetic reprogramming’ by which existing epigenetic chemical modifications to DNA and chromatin are removed on a genome wide level. The mechanisms of epigenetic reprogramming are essentially unknown. This student project aims to identify on a genome wide scale the genes which are reprogrammed and which chemical modifications are removed at what timepoint. This will open up the way for mechanistic studies which will help to unravel the secret of the immortal germline.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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