Award details

Determining the in vivo role of PLC-gamma2 using gene targeting technology

Reference	BBS/E/B/0000L479
Principal Investigator / Supervisor	Dr Martin Turner
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	46,756
Status	Completed
Type	Institute Project
Start date	26/01/2001
End date	01/08/2004
Duration	42 months

Abstract

B cells are responsible for the production of antibody molecules that bind to viruses and bacteria and inhibit their replication. Each B cell in the body produces a unique antibody that can be found at the cell surface. This cell surface antibody functions a receptor (called the B-cell receptor or BCR), which, when triggered causes a signal to be produced inside the cells. We are using biochemistry, genetics and in vivo studies to understand the signals generated by the receptor. This project uses a mouse model that lacks a specific component of the receptor signalling machinery. Our work is likely to have impact on the development of vaccines and in the control of diseases where antibody production is out of control.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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