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Microarray-mediated analysis of gene expression in the T lymphocyte lineage of the diabetes prone BB rat
Reference
BBS/E/B/0000L476
Principal Investigator / Supervisor
Dr Geoff Butcher
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
76,664
Status
Completed
Type
Institute Project
Start date
01/09/2000
End date
31/08/2004
Duration
48 months
Abstract
Autoimmune diseases, in which the immune system attacks the host, are frequently caused by failure of white blood cells, known as lymphocytes, to distinguish between self and non-self. The BB inbred strain of rat has been shown to develop autoimmune diabetes at a high frequency, whilst a closely related strain with very few genetic differences does not develop diabetes. The diabetes-prone strain has been shown to have a severe deficiency of mature T lymphocytes. We hope that by comparing T lymphocyte gene expression in the two strains using microarray technology, we may be able to elucidate the pathway leading to T lymphocyte deficiency.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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