Award details

Characterization of the PI3P-dependent signalling network responsible for nutrient sensing and autophagy

Reference	BBS/E/B/0000L246
Principal Investigator / Supervisor	Dr Nicholas Ktistakis
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	32,197
Status	Completed
Type	Institute Project
Start date	01/10/2009
End date	30/09/2012
Duration	36 months

Abstract

An important question in autophagy (a pathway that allows the breakdown of proteins inside the cell) concerns the mechanisms by which cells sense their extracellular (outside the cell) nutrient content. Recent work from many groups has indicated that a small lipid molecule called phosphatidylinositol 3 phosphate (PI3P) is an important signal for nutrient sensing. Our own work also indicates that autophagy is induced partially as a result of the formation of PI3P in specialised membrane compartments called omegasomes. Therefore, the mechanisms and signals that generate PI3P early during autophagy are likely to provide important information on the control of autophagy by nutrient sensing. The aim of this grant is to identify all human genes that are involved in this pathway. We plan to systematically silence all known human genes and then look at the effect that this will have in formation of PI3P during autophagy. By identifying all such genes we will be able to construct a wiring diagram of the cellular pathways that are implicated in nutrient sensing and respond during nutrient limitation by the induction of autophagy.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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