Award details

Identification and characterisation of 3D transcription networks in vivo

Reference	BBS/E/B/0000L204
Principal Investigator / Supervisor	Dr Peter Fraser
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	46,821
Status	Completed
Type	Institute Project
Start date	03/09/2007
End date	31/03/2012
Duration	55 months

Abstract

The mammlian genome consists of over 25,000 genes but only about half of them are expressed (copied into RNA which often encodes proteins) in any given cell type. Each cell type uses a unique subset of these genes while the rest are packaged away into condensed structures. Rather that being a simple string of DNA sequences our work and that of others has shown that genes interact with other genes and DNA sequences in the nucleus of cells in ways that can effect their activity. Not only do individual chromosomal strings of DNA fold in certain ways to affect gene activity, genes on different chromosomes can interact in 3 dimensional space to alter or affect gene activity. In this project we will use powerful new approaches to assess the spatial positioning of all active genes in the genome relative to two highly expressed genes in red blood cells. This will provide vital information to help us make sense of the genome and how it is controlled in health and disease.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search