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Role of imprinted nutrient transporters in fetal growth and development

Reference	BBS/E/B/0000L137
Principal Investigator / Supervisor	Dr Miguel Constancia
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	103,860
Status	Completed
Type	Institute Project
Start date	01/10/2004
End date	30/09/2009
Duration	60 months

Abstract

Imprinted genes, whose expression depends on whether they come from the father or mother, are key regulators of growth in mammalian species. We are using functional genomic approaches to elucidate the roles of an emerging class of physiologically important imprinted genes - transporter proteins. These proteins are likely to have important metabolic functions and physiological roles in fetal and placental growth and development. In particular, the activity and expression of placental nutrient transporters are primary determinants for the supply of nutrients to the fetus, and these nutrients in turn regulate fetal growth. This work will help understand the mechanisms of fetal growth restriction and may provide insights into fetal programming of adult diseases. Furthermore, elucidation of the mechanisms by which cells regulate nutrient availability may have important therapeutic applications, since there are many pathological circumstances associated with deregulation of nutrient metabolites for which nutritional or pharmacological interventions through such mechanisms may be of clinical benefit.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	Diet and Health
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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