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Role of phosphatidylinositol 3-kinase in B cell homeostasis and function

Reference	BBS/E/B/0000L111
Principal Investigator / Supervisor	Dr Martin Turner
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	134,768
Status	Completed
Type	Institute Project
Start date	01/04/2004
End date	31/03/2007
Duration	36 months

Abstract

The immune system has evolved to protect our bodies from the constant attack of harmful micro-organisms. To do this successfully the immune system utilises cells and molecules that convey information about the nature of the attacking micro-organisms and employs mechanisms to prevent the immune system from attacking our own cells (tolerance). This information is conveyed into the immune cell by cell by cell-surface receptors that are linked to molecules responsible for signal amplification, interpretation and attenuation (signal transduction). A large number of genes encoding proteins whose function is signal transduction have been discovered, but in many cases little is known regarding their importance or mode of action. Some of these proteins belongs to the PI3K family. This study will greatly enhance our knowledge of the role of individual PI3-K catalytic subunits in signalling pathways that control B cell homeostasis and activation. This knowledge may provide new insights into the fundmental biological processes regulated by PI3-K.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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