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In vivo analysis of higher order chromatin structure in an imprinting cluster
Reference
BBS/E/B/0000L109
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
142,595
Status
Completed
Type
Institute Project
Start date
01/04/2004
End date
30/04/2007
Duration
37 months
Abstract
Imprinted genes have key roles in mammalian development, particularly in regulating fetal and placental growth and placental function. A number of genes in the mouse are imprinted, resulting in only one copy being active, either the paternal or the maternal one. Many of these imprinted genes are located clustered together in specific region of the chromosome . We are interested in understanding how these genes clusters are regulated, and particularly, the role of chromatin modification and RNA. We are also interested in testing the hypothesis that `looping¿ of gene clusters brings distant DNA elements together and regulates gene expression.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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