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Novel technology to identify and study sequence elements involved in long-range gene regulatory interactions in vivo
Reference
BBS/E/B/0000L077
Principal Investigator / Supervisor
Dr Peter Fraser
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
73,571
Status
Completed
Type
Institute Project
Start date
01/04/2003
End date
30/04/2006
Duration
37 months
Abstract
Many genes require distal regulatory regions of DNA known as enhancers that are often located at a considerable distances from the gene along the chromosome. We have recently shown that distant enhancers actually physically contact their target genes in the nucleus by looping out the intervening DNA. Such long-range interactions between enhancers and genes are a powerful switch that turns on transcription of individual genes resulting in high levels of expression. Our work suggests that these regulatory interactions between enhancers and genes can only occur if the chromatin containing them is first remodelled to the open state by intergenic transcription. These are essential processes in the hierarchy of events in control of gene expression.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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