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Activation of Drosphila TRP channels: role of lipid messengers in regulating calcium influx
Reference
BBS/E/B/0000L070
Principal Investigator / Supervisor
Professor Raghu Padinjat
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
151,124
Status
Completed
Type
Institute Project
Start date
12/01/2002
End date
31/12/2005
Duration
48 months
Abstract
Numerous human and animal diseases are thought to arise from defective "Signal Transduction", the internal chemical language that cells use to monitor their surroundings and talk to other cells. Calcium ions are an important and widespread component of this chemical language used by animal cells. The main interest in our group is to understand how cells regulate intracellular calcium levels. Calcium is a second messenger that plays an important role in diverse biological processes such as fertilization, development and cell division. Understanding how calcuim signalling is regulated has implications for the treatment of heart disease, immune system dysfunction, stroke and neurodegenerative diseases. This project uses genetic analysis in the fruitfly Drosophila to understand how intracellular calcuim levels are regulated in animal cells.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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